top of page
Viruses and bacteria thrive in an acidic environment, acidification is crucial for viral replication
Honokiol and Magnolol has also been shown to inhibit CXCL10 and CXCL11 production in IL-27- stimulated human oral epithelial cells. These cytokines play a part in severe cases of the COVID-19 infection.
There are about 700 kinds of microorganisms that exist in the human mouth, and these microbes constitute the human oral microbiota. It is one of the most complex microbial communities in the human body.
The mouth is naturally a non-acidic environment. Bacteria convert sugars into acids through a process called glycolysis. The majority of viruses are acid-activated, meaning... viral membrane fusion depends on the exposure of the virus to low pH.
Once a virus infiltrates the host, it leads indirectly to increased extracellular acidity. Our saliva plays an important role in modulating the oral microbiota and the clearance of pathogens.
MAGNOLIA BARK EXTRACT RELATED STUDIES
-
Antimicrobial activity of honokiol and Magnolol- Our results indicate that honokiol and magnolol, although less potent than tetracycline, show a significant antimicrobial activity for periodontal pathogens. https://tinyurl.com/ybyrqw7o
-
Proinflammatory cytokines were identified as key molecules contributing to the destruction of periodontal tissues. The role of one cytokine, IL-1, in periodontal disease pathogenesis has been widely reported. [2] https://tinyurl.com/ya4aja56
-
Honokiol and Magnolol Inhibit CXCL10 and CXCL11
...has also been shown to inhibit CXCL10 and CXCL11 production in IL-27- stimulated human oral epithelial cells. These cytokines play a part in severe cases of the COVID-19 infection. [3] [3] https://www.ncbi.nlm.nih.gov/pubmed/30039429
-
Moreover, magnolol inhibited angiotensin-converting enzyme (ACE)/angiotensin II ... (Ang II)/Ang II type 1 receptor (AT-1R) cascade whereas upregulates ACE2 in the lungs of PAH rats [4] https://www.ncbi.nlm.nih.gov/pubmed/30466619
-
Magnolia bark extract has antimicrobial properties that could inhibit dental plaque. The antimicrobial properties of MBE suggest that it may be able to moderate the growth of oral bacteria https://tinyurl.com/ybjc3cfo
-
Magnolol and Honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)...The two compounds (Magnolol/Honokiol) showed active to extremely broad pathogenic microbial species. Apart from MSSA and MRSA, they showed as well antimicrobial activities against many other bacteria https://tinyurl.com/ydde8y96
-
The magic of pH When it comes to oral health, promoting a healthy pH can yield results that seem magical. This article discusses the basics of pH and remineralization, as well as new research into the buffering abilities of saliva. https://tinyurl.com/ybhc7juw
-
Scientists are reporting that breath mints made with magnolia bark extract kill most oral bacteria that cause bad breath and tooth decay within 30 minutes.
https://tinyurl.com/y8uaut6f
-
Biofilm-stimulated epithelium modulates the inflammatory responses. Chronic oral inflammation creates a constant immune response and can lead to other health conditions and a dysregulated, weakened or improper immune response. [1][1] https://www.nature.com/articles/s41598-019-52115-7
In the United States, magnolia bark extract has GRAS (Generally Recognized as Safe) status. Gum and mints containing magnolia bark extract have been allowed to be marketed since June 2008.
I know that was a mouthful if you are not familiar with these terms... the upregulation of ACE2 and inhibition of ANG et al...this article explains in detail [10] [10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167588/
“An alkaline body can absorb up to 20 times more oxygen than an acidic body.” Dr Otto Warburg, a Nobel Prize Winner for his work on respiratory enzymes and cancer.
Upper respiratory tract infections are probably the most common infections in the world.
Experts are looking at mouthwash to see if it can help stop the spread of COVID-19
At the same time, some of these mouthwash solutions end up killing all bacterias and microorganism including beneficial bacteria in the host epithelial. And there are other problems with the idea. Like toxicity. And no solid science.
“Some of these agents, such as ethanol and hydrogen peroxide, may, if used several times a day over a period of two to three months, induce inflammation” in the mouth and throat, warned the British team, led by Valerie B. O’Donnell, director of the division of infection and immunity at Cardiff University School of Medicine.
One of the most common and extensively used oral antiseptic and antiplaque is Chlorhexidine Gluconate. This is the same ingredient used in surgical hand scrub (do you really want this in your mouth?) However, its long-term use is associated with a number of adverse side effects and kills all bacteria including beneficial bacteria in the host epithelial. [9] [9] https://pubmed.ncbi.nlm.nih.gov/26600203/
Magnolia Bark Extracts in a study was to be as effective as Chlorhexidine and without the toxicity. [6] [6] https://www.webmd.com/oral-health/news/20071116/magnolia-bark-extract-vs-bad-breath
Along with MBE, MAG7 is formulated with the extracts of natural phytochemicals from plants like Sage, Olive leaf, Plantain leaf, Artemisia Annua, Salvia Miltiorrhiza, OSHA/Ligusticum porteri to name few... all which have been studied for their pharmacological activities, which has been the focus of attraction for scientists
The airway epithelium is central to the defence of the lungs against pathogens.
It acts as a physical barrier against pollutants, pathogens and harmless inhaled particles from the external environment.
bottom of page